Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease.

The role of Inositol 1,4,5 triphosphate kinase C in the pathogenesis of Kawasaki disease

Background Kawasaki disease (KD) is a childhood multisystemic vasculitis resulting in the development of coronary aneurysms. Functional polymorphism in Inositol 1,4,5-triphosphate kinase C (ITPKC) has recently been identified and linked to KD susceptibility and severity. ITPKC acts as a negative regulator of T-cell activation through the inhibition of Ca/Nuclear factor of activated T-cells (NFA...

Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease.

Kawasaki disease is the most common cause of vasculitis affecting children, and the leading cause of acquired heart disease in the developed world. To date, studies on the role of IFN-gamma in the pathogenesis of Kawasaki disease have focused on peripheral production of IFN-gamma, and have yielded conflicting results. Affected heart tissue is not available from children with Kawasaki disease. I...

Presence of IFN- Does Not Indicate Its Necessity for Induction of Coronary Arteritis in an Animal Model of Kawasaki Disease

Biol. Pharm. Bull. 29(9) 1854—1861 (2006)

quently induces deep mycosis and fungemia, especially in immunocompromised hosts. Pathogenic microbes have various toxic mechanisms that are unique to each species and are essential for survival and evolution. Pathogenic mechanisms of eukaryotic microbes are complicated compared to those of bacteria and viruses. Although there have been extensive basic and clinical studies, the major pathogenic...

TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease.

BACKGROUND Kawasaki disease is the most common cause of acquired cardiac disease and acute vasculitis in children, targets the coronary arteries, and can occasionally be fatal. The pathogenesis and the molecular mechanisms remain unknown. After injection of Lactobacillus casei cell-wall extract (LCCWE), mice develop a focal coronary arteritis that histopathologically resembles Kawasaki disease,...